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. 2025 Oct 17.
doi: 10.1007/s11418-025-01962-y. Online ahead of print.

New prunasin derivatives, bachmasides A and B, with α-glucosidase inhibitory activity from the leaves of Elaeocarpus bachmaensis

Phan Thi Diem Tran  1   2 , Vu Thi Thanh Tam  1 , Tran Phuong Ha  1 , Le Tuan Anh  1 , Le Trung Hieu  2 , Ton That Huu Dat  3 , Le Canh Viet Cuong  4
Affiliations

New prunasin derivatives, bachmasides A and B, with α-glucosidase inhibitory activity from the leaves of Elaeocarpus bachmaensis

Phan Thi Diem Tran et al. J Nat Med. .

Abstract

Two new prunasines, bachmasides A and B (1-2), together with five known compounds, methyl 6-O-p-trans-coumaroyl-β-D-glucopyranoside (3), methyl 6-O-feruloyl-β-D-glucopyranoside (4), polystachyol (5), ethyl (6-O-p-hydroxybenzoyl)-β-D-glucopyranoside (6), and prunasin (7) were isolated from leaves of Elaeocarpus bachmaensis. The structures of isolated compounds (1-7) were elucidated by 1D-NMR, 2D-NMR, and HRMS spectra. The inhibition assays showed that compound 5 significantly inhibited α-amylase with IC50 value of 90.2 ± 11.5 µg/ml, whereas compounds 1, 2, 4 and 6 significantly inhibited α-glucosidase with IC50 values ranging from 42.4 ± 5.4 to 75.4 ± 5.6 µg/ml, considerably lower than those of acarbose (IC50 of 112.1 ± 3.1 and 133.0 ± 4.4 µg/ml, respectively). These findings suggest that E. bachmaensis may be a promising source of antidiabetic agents.

Keywords: Elaeocarpus bachmaensis; Antidiabetic activity; α-Amylase; α-Glucosidase.

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Conflict of interest statement

Declarations. Conflict of interest: All the authors have no conflicts of interest to declare.

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