Declaration of Interests M.S. has nothing to disclose. A.B. reports Equity in Fellow Health. D.N. is an independent contractor (Data Scientist) for Fellow Health Inc., provided data analysis support for this project, and was paid as an independent contractor. K.S. reports honoraria from EMD Serono; board member for True North Treks Alliance for Fertility Preservation. J.R. is Executive Director (paid role) for Alliance for Fertility Preservation Nonprofit organization. J.M. has nothing to disclose. S.A.K. reports stock options Fellow Health, Inc. Y.L. has nothing to disclose. D.C. reports Analytics Consulting Independent data science and engineering consultant (approx. 10 hours/week); consulting not related to the present manuscript; pending patent: “Methods and Systems for Methylation Pattern Characterization and Profiling of Nucleic Acid Samples.” Patent filed with Fellow Health; unrelated to the submitted manuscript; stock options; Analytics Consulting, consulting for Fellow Health. K.E.O. is the advisor and cofounder of Paterna Biosciences; patents PCT/US2018/043948 and PCT/US2019/065006; President, American Society of Andrology; stock options Paterna Biosciences.J.F.S. is Chief Medical Officer Fellow Health. Data provided by Fellow Health for submitted work; travel support from UCSF Dept of Urology and Fellow Health; Past President Society Male Reproduction Urology, Past President Society Study Male Reproduction, Vice President, American Society Andrology, Member, American Society Clinical Oncology Guidelines Committee, Past-Chair, Fertility Preservation Special Interest Group (ASRM); stock options Fellow Health, Inherent Biosciences, Posterity Health.