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Review
. 2025 Oct;34(4):527-541.
doi: 10.1016/j.soc.2025.03.009. Epub 2025 May 16.

Diagnosis and Staging Lung Cancer with Modern Tools

Affiliations
Review

Diagnosis and Staging Lung Cancer with Modern Tools

Camille Yongue et al. Surg Oncol Clin N Am. 2025 Oct.

Abstract

Lung cancer remains the leading cause of cancer-related deaths, with increased incidental nodules and a higher incidence in young female individuals. Effective screening and evaluation are vital for early lung cancer detection, while advancing imaging with radiomics and PET/computed tomography help assess the risk of malignancy. Nonsurgical diagnostic procedures include bronchoscopic and image-guided biopsy, while surgical biopsies for diagnosis can be aided by multiple intraoperative colocalization techniques. Accurate staging, particularly of lymph nodes, and molecular testing are essential for treatment planning and prognostication.

Keywords: Biopsy; Bronchoscopy; Diagnosis; Lung cancer; Lung cancer screening; Pulmonary nodules; Staging.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.

MeSH terms