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Review
. 2025 Oct 20.
doi: 10.1002/acr.25673. Online ahead of print.

Climate Change, Environmental Risk Factors, and Gout

Mary L Guan  1   2 , Tamiko R Katsumoto  3 , Michael Toprover  1   2 , Nidaa Rasheed  4   5 , Shuchi Anand  6 , Michael H Pillinger  1   2 , Michael H Weisman  3 , Suzanne R Tamang  3   7
Affiliations
Review

Climate Change, Environmental Risk Factors, and Gout

Mary L Guan et al. Arthritis Care Res (Hoboken). .

Abstract

Worldwide, gout is increasing at a rapid rate. Although genetics and diet play primary roles in gout development, emerging evidence suggests that environmental risk factors may also play a significant contributory role. In this review, we examine the evidence linking environmental exposures to gout risk, summarize potential pathophysiologic mechanisms, and highlight key knowledge gaps and underexplored areas. In particular, we highlight the impact of air pollution, ambient temperature, water contamination with heavy metals, chronic kidney disease (as it relates both to gout and climate change), dietary factors such as ultraprocessed food consumption, and various other pollutants in increasing the risk of gout.

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References

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