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. 2025 Sep 27:42:e02384.
doi: 10.1016/j.idcr.2025.e02384. eCollection 2025.

Oral syphilis: The Great Masquerader

Aaesha Saeed Alshehhi  1 , Najla Saleh Ben Ghashir  2 , Robert Lodu Serafino Wani Swaka  1   3 , Zahir Osman Eltahir Babiker  1   3
Affiliations

Oral syphilis: The Great Masquerader

Aaesha Saeed Alshehhi et al. IDCases. .

Abstract

•Histopathological examination improves the accuracy of diagnosing oral syphilis.

Keywords: Immunohistochemical staining; Oral syphilis; Papillomatous lesion; Treponema pallidum.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
A) Nodular lesions on the dorsal aspect of the tongue associated with intervening serpiginous whitish patches, (1.B) H&E stained section at low power [x5 magnification] showing hyperplastic oral squamous mucosa with dense active chronic inflammation in the epithelium and stroma, (1.C) H&E stained section at higher [x20 magnification] showing plasma cell-rich inflammation in subepithelial stroma, (1.D) Spirochete immunohistochemical stain [x40 magnification] showing abundant brown-coloured spirochetes in the squamous epithelium and the inflamed stroma.
See this image and copyright information in PMC

References

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