Anti-inflammatories for depression: challenges and ASPIRations

Courtney Worrell¹, Bernhard T Baune², Francesco Benedetti³, Annamaria Cattaneo⁴, Livia De Picker⁵, Jennifer C Felger⁶, Stefan M Gold⁷, Femke Lamers⁸, Marion Leboyer⁹, Giulia Lombardo¹, Fanni-Laura Mäntylä¹⁰, Andrew H Miller⁶, Valeria Mondelli¹¹, Brenda W J H Penninx⁸, Luca Sforzini¹¹, Dan J Stein¹², Benedetta Vai³, Erik Van der Eycken¹⁰, Anthony Woods¹, Carmine M Pariante¹³; ASPIRE Study Consortium

Collaborators, Affiliations

Collaborators

ASPIRE Study Consortium:
Bruno Aouizerate, Bernhard T Baune, Veronica Begni, Francesco Benedetti, Michael Berk, Igor Branchi, Beatrice Bravi, Nadia Cattane, Annamaria Cattaneo, Tommaso Cazzella, Federico Cevoli, Cassey Chambers, Violette Coppens, Christopher Davey, Floriana De Cillis, Livia De Picker, Olivia Dean, Claudia Delli Colli, Linda El-Ahmad, Jennifer C Felger, Éimear M Foley, Pierrette Fortuna, Sarah Fromme, Stefan M Gold, Luisa Grünberg, Kate Hamilton, Ebrahim Haroon, Neil Harrison, Ben Harrison, Julian Hellmann-Regen, Isabella Heuser, Nadia Hoffman, Krystle Kemp, Golam M Khandaker, Anastasia Kontogianni, Melisa Kose, Femke Lamers, Toni Lange, Marion Leboyer, Giulia Lombardo, Fanni-Laura Mäntylä, Nicole Mariani, Yuri Milaneschi, Andrew H Miller, Valeria Mondelli, Camilla Monopoli, Manuel Morrens, Naghmeh Nikkheslat, Nigel Olisa, Christian Otte, Carmine M Pariante, Brenda W J H Penninx, Caitlin Pentland, Sara Poletti, Camila Ribeiro Perez, Luca Sforzini, Maria Simon, Claudio Singh Solorzano, Dan J Stein, Victoria Stiglbauer, Michael T Treadway, Benedetta Vai, Erik Van der Eycken, Chiara Verga, Céline Wessa, Anthony Woods, Courtney Worrell, Deniz Yildirim Dogan, Zuzanna Zajkowska, Joël Zwiep

Affiliations

¹ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK.
² Department of Psychiatry, University of Münster, Münster, Germany.
³ Division of Neuroscience, Psychiatry & Clinical Psychobiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.
⁴ Biological Psychiatric Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
⁵ University Psychiatric Hospital Campus Duffel, Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute, Faculty of Health Sciences, University of Antwerp, Antwerp, Belgium.
⁶ Department of Psychiatry and Behavioural Sciences, Emory University School of Medicine, Atlanta, GA, USA.
⁷ Department of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁸ Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.
⁹ FondaMental Foundation, Créteil, France; Department of Addictology and Psychiatry, Université Paris-Est Créteil, AP-HP, Translational Neuropsychiatry laboratory, Inserm U955, PEPR PROPSY, Créteil, France.
¹⁰ Global Alliance of Mental Illness Advocacy Networks-Europe, Brussels, Belgium.
¹¹ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK; National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
¹² SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹³ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK; National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK. Electronic address: carmine.pariante@kcl.ac.uk.

PMID: 41115445
DOI: 10.1016/S2215-0366(25)00308-6

Anti-inflammatories for depression: challenges and ASPIRations

Courtney Worrell et al. Lancet Psychiatry. 2025.

. 2025 Oct 17:S2215-0366(25)00308-6.

doi: 10.1016/S2215-0366(25)00308-6. Online ahead of print.

Authors

Collaborators

ASPIRE Study Consortium:
Bruno Aouizerate, Bernhard T Baune, Veronica Begni, Francesco Benedetti, Michael Berk, Igor Branchi, Beatrice Bravi, Nadia Cattane, Annamaria Cattaneo, Tommaso Cazzella, Federico Cevoli, Cassey Chambers, Violette Coppens, Christopher Davey, Floriana De Cillis, Livia De Picker, Olivia Dean, Claudia Delli Colli, Linda El-Ahmad, Jennifer C Felger, Éimear M Foley, Pierrette Fortuna, Sarah Fromme, Stefan M Gold, Luisa Grünberg, Kate Hamilton, Ebrahim Haroon, Neil Harrison, Ben Harrison, Julian Hellmann-Regen, Isabella Heuser, Nadia Hoffman, Krystle Kemp, Golam M Khandaker, Anastasia Kontogianni, Melisa Kose, Femke Lamers, Toni Lange, Marion Leboyer, Giulia Lombardo, Fanni-Laura Mäntylä, Nicole Mariani, Yuri Milaneschi, Andrew H Miller, Valeria Mondelli, Camilla Monopoli, Manuel Morrens, Naghmeh Nikkheslat, Nigel Olisa, Christian Otte, Carmine M Pariante, Brenda W J H Penninx, Caitlin Pentland, Sara Poletti, Camila Ribeiro Perez, Luca Sforzini, Maria Simon, Claudio Singh Solorzano, Dan J Stein, Victoria Stiglbauer, Michael T Treadway, Benedetta Vai, Erik Van der Eycken, Chiara Verga, Céline Wessa, Anthony Woods, Courtney Worrell, Deniz Yildirim Dogan, Zuzanna Zajkowska, Joël Zwiep

Affiliations

¹ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK.
² Department of Psychiatry, University of Münster, Münster, Germany.
³ Division of Neuroscience, Psychiatry & Clinical Psychobiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.
⁴ Biological Psychiatric Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
⁵ University Psychiatric Hospital Campus Duffel, Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute, Faculty of Health Sciences, University of Antwerp, Antwerp, Belgium.
⁶ Department of Psychiatry and Behavioural Sciences, Emory University School of Medicine, Atlanta, GA, USA.
⁷ Department of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁸ Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.
⁹ FondaMental Foundation, Créteil, France; Department of Addictology and Psychiatry, Université Paris-Est Créteil, AP-HP, Translational Neuropsychiatry laboratory, Inserm U955, PEPR PROPSY, Créteil, France.
¹⁰ Global Alliance of Mental Illness Advocacy Networks-Europe, Brussels, Belgium.
¹¹ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK; National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
¹² SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹³ Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 9RT, UK; National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK. Electronic address: carmine.pariante@kcl.ac.uk.

PMID: 41115445
DOI: 10.1016/S2215-0366(25)00308-6

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Conflict of interest statement

The following authors report consultancy or speaker fees: LDP (Boehringer Ingelheim Belgium); SMG (Hexal, Tegus, Angelini, and Streamed up); FL (Noema Pharma, Novo Nordisk, and Johnson & Johnson); JCF (Ventus Therapeutics); BVJHP (Neurotorium and Boehringer Ingelheim); BTB (AstraZeneca, Lundbeck, Pfizer, Takeda, Servier, Bristol Myers Squibb, Otsuka, LivaNova, Biogen, Angelini, and Janssen–Cilag); AHM (Cerevel Therapeutics, Freedom Biosciences, and Sirtsei Pharmaceuticals); DJS (Discovery Vitality, Johnson & Johnson, Kanna, L’Oréal Lundbeck, Orion, Sanofi, Servier, Takeda, and Vistagen); and CMP (Värde Partners, Compass Pathways, and UCB). All other authors declare no competing interests. This work was supported by the Wellcome Trust Advanced Stratification of People with Depression (ASPIRE) Study (30312/Z/23/Z).

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Anti-inflammatories for depression: challenges and ASPIRations

Collaborators

Affiliations

Anti-inflammatories for depression: challenges and ASPIRations

Authors

Collaborators

Affiliations

Conflict of interest statement

LinkOut - more resources

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