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Editorial
. 2025 Oct 1;15(5):409-410.
doi: 10.31661/jbpe.v0i0.2509-1985. eCollection 2025 Oct.

From Clinics to Cosmos: Radiotherapy as a Selector for Stress-Resistant Microbiota

Seyed Mohammad Javad Mortazavi  1   2 , Joseph J Bevelacqua  3 , Maryam Arshadi  1 , James Welsh  4   5
Affiliations
Editorial

From Clinics to Cosmos: Radiotherapy as a Selector for Stress-Resistant Microbiota

Seyed Mohammad Javad Mortazavi et al. J Biomed Phys Eng. .
No abstract available

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Conflict of interest statement

SMJ. Mortazavi and J. Welsh, as the Editorial Board Members, were not involved in the peer-review and decision-making processes for this manuscript.

Figures

Figure 1
Figure 1
Conceptual model illustrating how Radiotherapy (RT), delivered at sub-inhibitory/sub-inactivation doses for gut microorganisms, may exert selective pressures on the microbiota. Two main pathways are proposed: (1) Dysbiosis and immune weakening through loss of beneficial taxa and enrichment of pathobionts, leading to impaired anti-tumor immunity; and (2) Horizontal Gene Transfer (HGT) and spread of antibiotic resistance, contributing to increased infections and reduced treatment tolerance. Both pathways ultimately converge on reduced efficacy of radiotherapy. (SCFA: Short-Chain Fatty Acids)
See this image and copyright information in PMC

References

    1. Mortazavi SMJ, Said-Salman I, Mortazavi SAR, El Khatib S, Sihver L. How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond. Front Microbiol. 2024;14:1237564. doi: 10.3389/fmicb.2023.1237564. [ PMC Free Article ] - DOI - PMC - PubMed
    1. Rithidech KN, Peanlikhit T, Honikel L, Li J, Liu J, Karakach T, et al. Consumption of Apigenin Prevents Radiation-induced Gut Dysbiosis in Male C57BL/6J Mice Exposed to Silicon Ions. Radiat Res. 2024;201(4):317–29. doi: 10.1667/RADE-23-00110.1. - DOI - PubMed

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