Beating-wave analysis of small-angle X-ray scattering of unilamellar liposomes loaded with model drug Benzocaine

Abstract

A robust mathematical model was developed to characterize the liposomal bilayer via small-angle X-ray scattering (SAXS). The model was tested on four liposome formulations having the same excipients but different loaded drugs, demonstrating high accuracy in drawing the electron density profiles, highlighting their differences.