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Review
. 2025 Dec;54(4):627-635.
doi: 10.1016/j.ecl.2025.08.003.

Medical Therapies of Cushing's Disease-Part 2

Yair Schwarz  1 , Elisabeth Nowak  2 , Reut Halperin  3 , Shruti N Shah  4 , Nidhi Agrawal  5 , Richard A Feelders  6
Affiliations
Review

Medical Therapies of Cushing's Disease-Part 2

Yair Schwarz et al. Endocrinol Metab Clin North Am. 2025 Dec.

Abstract

Cushing's disease (CD) is an endogenous hypercortisolism state caused by an adrenocorticotropic hormone (ACTH) secreting pituitary adenoma. Medical therapy is an important second-line treatment for CD. New pharmacologic agents for the treatment of patients with CD are under development. New possible intervention targets include various receptors and pathways in the corticotroph tumor, the hormone ACTH, and its receptor and enzymes involved in cortisone metabolism. This part of the article will focus on tailoring pharmacologic therapy according to patient specific characteristics, long-term medical therapy and development of new drugs for CD.

Keywords: Cushing disease new drugs; Cushing medications; Cushing tailored therapy; Cushing’s disease; Novel treatment targets in cushing.

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Conflict of interest statement

Disclosure R.A. Feelders has received speaker fees and research grants from Recordati and Corcep, N. Agrawal had a research grant form Recordati. Y. Schwarz, R. Halperin, E. Nowak and S.N. Shah have nothing to declare.

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