NY-ESO-1 targeting in non-small cell lung cancer: promise and challenges of letetresgene autoleucel
- PMID: 41132970
- PMCID: PMC12541852
- DOI: 10.21037/tlcr-2025-625
NY-ESO-1 targeting in non-small cell lung cancer: promise and challenges of letetresgene autoleucel
Keywords: New York esophageal squamous cell carcinoma 1 (NY-ESO-1); Non-small cell lung cancer (NSCLC); TCR-T therapy; adoptive cell therapy; letetresgene autoleucel (lete-cel).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-625/coif). R.C. reports grants paid to Institution by Roche, AstraZeneca, Pfizer, Clovis, Lilly Oncology, MSD, BMS, Abbvie, Takeda, Janssen, and Novartis; and consulting fees from AstraZeneca, Boeringher Ingelheim, Lilly Oncology, Roche, Pfizer, MSD, BMS, Takeda, Janssen, Bayer, and Novartis. The other authors have no conflicts of interest to declare.
Comment on
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Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non-Small Cell Lung Cancer.Clin Cancer Res. 2025 Feb 3;31(3):529-542. doi: 10.1158/1078-0432.CCR-24-1591. Clin Cancer Res. 2025. PMID: 39576208 Free PMC article. Clinical Trial.
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