doi: 10.1126/science.176.4038.1027.
Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody
- PMID: 4113485
- DOI: 10.1126/science.176.4038.1027
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Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody
Science.
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Abstract
Spleen cells from BALB/c mice immunized with heat-killed rough pneumococci (strain R36A) or spleen cells from normal mice immunized in vitro with the same antigen produce direct hemolytic plaques against sheep erythrocytes coated with pneumococcal C polysaccharide or conjugated with phosphorylcholine. Formation of plaques is specifically inhibited by phosphorylcholine or by antiserum to mouse immunoglobulin A myeloma protein which binds phosphorylcholine. Thus, the myeloma proteins and normal BALB/c antibodies share similar idiotypic determinants. This experimental system is suitable for probing the role of the antigen receptor in the immune response.
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