Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 May;69(5):1128-30.
doi: 10.1073/pnas.69.5.1128.

Inhibition of aggregation and differentiation of Dictyostelium discoideum by antibodies against adenosine 3':5'-cyclic monophosphate diesterase

E A Goidl, B M Chassy, L L Love, M I Krichevsky

Inhibition of aggregation and differentiation of Dictyostelium discoideum by antibodies against adenosine 3':5'-cyclic monophosphate diesterase

E A Goidl et al. Proc Natl Acad Sci U S A. 1972 May.

Abstract

A specific antibody directed against adenosine 3':5'-cyclic monophosphate diesterase (c-AMP diesterase; EC 3.1.4.c), which is secreted by the amoeboid slime mold, Dictyostelium discoideum, was prepared in rabbits. Purified gammaglobulin fractions that contain the antibodies inhibited the activity of cAMP diesterase preparations in vitro and interfered with aggregation and development in vivo. While cells that were treated with antibody were unable to aggregate because of the inability to destroy cAMP, they aggregated normally when washed free of antibody.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152-4 - PubMed
    1. Science. 1968 Jul 5;161(3836):57-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Sep;64(1):296-303 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Jan;65(1):110-3 - PubMed
    1. J Theor Biol. 1970 Mar;26(3):399-415 - PubMed