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. 1972 Jun;69(6):1540-4.
doi: 10.1073/pnas.69.6.1540.

Myeloma proteins as tumor-specific transplantation antigens

R G Lynch, R J Graff, S Sirisinha, E S Simms, H N Eisen

Myeloma proteins as tumor-specific transplantation antigens

R G Lynch et al. Proc Natl Acad Sci U S A. 1972 Jun.

Abstract

BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.

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