HPV vaccination is associated with lower risk of cancers among female

Yao-Min Hung¹, Ting-An Lin², Shiow-Ing Wang³, Pei-Ju Wu⁴, Renin Chang⁵, James Cheng-Chung Wei⁶

Affiliations

¹ Division of Nephrology, Department of Internal Medicine, Taitung Hospital, Ministry of Health and Welfare, Taitung, Taiwan; Master of Biomedicine Program, College of Science and Engineering, National Taitung University, Taitung, Taiwan; College of Health and Nursing, Meiho University, Pingtung, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address: ymhung1@gmail.com.
² School of Medicine, Chung Shan Medical University, Taichung City, Taiwan. Electronic address: lintinazxcv@gmail.com.
³ Center for Health Data Science, Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address: shiowing0107@gmail.com.
⁴ Department of Medical Research and Education, Taipei, Ministry of Health & Welfare, the Executive Yuan, Taiwan. Electronic address: rhapsody1881@gmail.com.
⁵ Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Recreation Sports Management, Tajen University, Pingtung, Taiwan. Electronic address: rhapsody1881@gmail.com.
⁶ Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; Institute of Medicine/Department of Nursing, Chung Shan Medical University, Taichung, Taiwan; Office of Research and Development, Asia University, Taichung, Taiwan. Electronic address: wei3228@gmail.com.

PMID: 41138956
DOI: 10.1016/j.amjmed.2025.10.016

HPV vaccination is associated with lower risk of cancers among female

Yao-Min Hung et al. Am J Med. 2025.

. 2025 Oct 23:S0002-9343(25)00715-6.

doi: 10.1016/j.amjmed.2025.10.016. Online ahead of print.

Authors

Yao-Min Hung¹, Ting-An Lin², Shiow-Ing Wang³, Pei-Ju Wu⁴, Renin Chang⁵, James Cheng-Chung Wei⁶

Affiliations

¹ Division of Nephrology, Department of Internal Medicine, Taitung Hospital, Ministry of Health and Welfare, Taitung, Taiwan; Master of Biomedicine Program, College of Science and Engineering, National Taitung University, Taitung, Taiwan; College of Health and Nursing, Meiho University, Pingtung, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address: ymhung1@gmail.com.
² School of Medicine, Chung Shan Medical University, Taichung City, Taiwan. Electronic address: lintinazxcv@gmail.com.
³ Center for Health Data Science, Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address: shiowing0107@gmail.com.
⁴ Department of Medical Research and Education, Taipei, Ministry of Health & Welfare, the Executive Yuan, Taiwan. Electronic address: rhapsody1881@gmail.com.
⁵ Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Recreation Sports Management, Tajen University, Pingtung, Taiwan. Electronic address: rhapsody1881@gmail.com.
⁶ Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; Institute of Medicine/Department of Nursing, Chung Shan Medical University, Taichung, Taiwan; Office of Research and Development, Asia University, Taichung, Taiwan. Electronic address: wei3228@gmail.com.

PMID: 41138956
DOI: 10.1016/j.amjmed.2025.10.016

Abstract

Background: HPV vaccines prevent certain cancers, but the broader long-term effects are unclear. We assessed whether HPV vaccination is associated with cancer risk among females aged 9-26 years.

Methods: Retrospective cohort study in the TriNetX U.S. Collaborative Network (Jan 1, 2013-Dec 31, 2022) comparing HPV-vaccinated vs unvaccinated females after 1:1 PSM; Cox proportional-hazards models estimated HRs (95% CIs), with subgroup analyses by age, race/ethnicity, and vaccine valence, and sensitivity analyses using active comparators (influenza- and HBV-vaccinated) and a health check-up cohort.

Results: The findings showed that HPV vaccination was significantly associated with overall cancer risk (HR 0.38, 95% CI 0.34-0.42), with greater reduction when initiated at ages 9-14 vs 15-26 (HR 0.37 vs 0.54). Both 9vHPV and 4vHPV vaccines lowered cancer risks, with consistent support from sensitivity analyses.

Conclusions: In this multi-institutional retrospective cohort, HPV vaccination was associated with lower incidence of several cancers among females aged 9-26 years.

Keywords: HPV vaccination. cancers; cohort study;TriNetX.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest: Yao-Min Hung; Ting-An Lin; Shiow-Ing Wang; Pei-Ju Wu; Renin Chang; James Cheng-Chung Wei.

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HPV vaccination is associated with lower risk of cancers among female

Affiliations

HPV vaccination is associated with lower risk of cancers among female

Authors

Affiliations

Abstract

Conflict of interest statement

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous