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. 2025 Oct 27:e255465.
doi: 10.1001/jamainternmed.2025.5465. Online ahead of print.

Durability of 2024-2025 COVID-19 Vaccines Against JN.1 Subvariants

Yi Du  1 , Sai Paritala  1 , Yangjianchen Xu  2 , Patrick Maloney  3 , Dan-Yu Lin  4
Affiliations

Durability of 2024-2025 COVID-19 Vaccines Against JN.1 Subvariants

Yi Du et al. JAMA Intern Med. .
No abstract available

Plain language summary

This observational study assesses the durability of protection provided by updated COVID-19 vaccines over a 7-month period, during which circulating SARS-CoV-2 variants were predominantly JN.1 descendants.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Comment in

  • doi: 10.1001/jamainternmed.2025.5462

References

    1. FDA approves and authorizes updated mRNA COVID-19 vaccines to better protect against currently circulating variants. Press release. US Food and Drug Administration. Published August 22, 2024. Accessed September 25, 2025. https://www.fda.gov/news-events/press-announcements/fda-approves-and-aut...
    1. FDA authorizes updated Novavax COVID-19 vaccine to better protect against currently circulating variants. Press release. US Food and Drug Administration. Published August 30, 2024. Accessed September 25, 2025. https://www.fda.gov/news-events/press-announcements/fda-authorizes-updat...
    1. Lin DY, Du Y, Xu Y, Paritala S, Donahue M, Maloney P. Durability of XBB.1.5 vaccines against omicron subvariants. N Engl J Med. 2024;390(22):2124-2127. doi: 10.1056/NEJMc2402779 - DOI - PMC - PubMed

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