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. 1972 Jul;23(1):13-8.

The mitogenic effects of isologous nuclear material

G D Pegrum, D J Perera, E Thompson

The mitogenic effects of isologous nuclear material

G D Pegrum et al. Immunology. 1972 Jul.

Abstract

The nuclear material from human lymphocytes stimulated with phytohaemagglutinin (PHA) will produce a marked increase of DNA synthesis in unstimulated isologous lymphocytes which is far in excess of the normal response to PHA by the same lymphocytes. It is postulated that release of nuclear complexes from a few lymphocytes transformed in response to a specific stimulus is responsible for the transformation produced in surrounding lymphocytes which are non-responsive to the initial antigenic challenge.

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References

    1. Br J Haematol. 1965 Nov;11(6):642-5 - PubMed
    1. Nature. 1967 Feb 18;213(5077):676-8 - PubMed
    1. J Pathol Bacteriol. 1968 Jul;96(1):187-201 - PubMed
    1. Nature. 1969 Mar 22;221(5186):1155-7 - PubMed
    1. Nature. 1969 Jun 28;222(5200):1247-50 - PubMed

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