Isolation and characterization of IgG globulins in subacute sclerosing panencephalitis
- PMID: 4114651
- PMCID: PMC1407780
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Isolation and characterization of IgG globulins in subacute sclerosing panencephalitis
Immunology.
1972 Jul.
Abstract
Patients affected with subacute sclerosing panencephalitis were found to show high measles antibody activity; γ-globulin M-components were detected in the serum, cerebrospinal fluid and brain tissue. The relative antibody activity was different in the different IgGs separated by gel filtration. The γ-globulins were separated into several components by isoelectric focussing on a sucrose gradient and each showed different degrees of measles antibody activity. Better separation was achieved by isoelectric focusing than by gel chromatography.
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