Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 Oct;16(5):1457-1464.
doi: 10.1055/a-2702-6872. Epub 2025 Oct 28.

Applying an Empirical Taxonomy to Alert Malfunctions in a Pragmatic Trial for Hypertension Management in Chronic Kidney Disease

Affiliations
Randomized Controlled Trial

Applying an Empirical Taxonomy to Alert Malfunctions in a Pragmatic Trial for Hypertension Management in Chronic Kidney Disease

Sarah W Chen et al. Appl Clin Inform. 2025 Oct.

Abstract

Clinical decision support (CDS) systems have been widely adopted across clinical settings to promote evidence-based practice for clinicians. CDS malfunctions often affect the user experience and indirectly or directly interfere with patient care. To enhance optimal performance, it is critical to constantly monitor the performance of the tool and react promptly when malfunctions are identified.This study aimed to describe malfunctions identified in the development and implementation of a CDS alert as well as lessons learned.A pragmatic randomized controlled trial of a CDS alert for primary care patients with chronic kidney disease and uncontrolled blood pressure was conducted. The alert included prechecked default orders for medication initiation or titration, basic metabolic panel, and nephrology electronic consult. Alert monitoring involved retrospective chart review and review of alert firing reports.Eight CDS malfunctions were identified. The most common causes of malfunctions were due to conceptualization and build errors. Provider feedback and retrospective chart review were the primary methods of identifying the root cause of malfunctions.Our findings highlight the need for CDS interventions to be continuously monitored through chart review, alert firing reports, and opportunities for provider feedback. Lessons learned from CDS malfunctions can be implemented to improve provider trust in automated electronic health record-based alerts, reduce administrative burden, and prevent inappropriate alert recommendations that can negatively affect patient outcomes. This study is registered with Clinivaltrials.gov (identifier: NCT03679247).

PubMed Disclaimer

Conflict of interest statement

None declared.

References

    1. Sutton R T, Pincock D, Baumgart D C, Sadowski D C, Fedorak R N, Kroeker K I. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. 2020;3:17. - PMC - PubMed
    1. Sirajuddin A M, Osheroff J A, Sittig D F, Chuo J, Velasco F, Collins D A. Implementation pearls from a new guidebook on improving medication use and outcomes with clinical decision support. Effective CDS is essential for addressing healthcare performance improvement imperatives. J Healthc Inf Manag. 2009;23(04):38–45. - PMC - PubMed
    1. Wright A, Hickman T T, McEvoy D et al. Analysis of clinical decision support system malfunctions: a case series and survey. J Am Med Inform Assoc. 2016;23(06):1068–1076. - PMC - PubMed
    1. Wright A, Ai A, Ash J et al. Clinical decision support alert malfunctions: analysis and empirically derived taxonomy. J Am Med Inform Assoc. 2018;25(05):496–506. - PMC - PubMed
    1. Kassakian S Z, Yackel T R, Gorman P N, Dorr D A. Clinical decisions support malfunctions in a commercial electronic health record. Appl Clin Inform. 2017;8(03):910–923. - PMC - PubMed

Publication types

MeSH terms

Associated data