doi: 10.1007/BF01683719.
The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats
- PMID: 411532
- DOI: 10.1007/BF01683719
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The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats
Bull Environ Contam Toxicol.
1977 Oct.
Abstract
We investigated the effect of banol and paraoxon on the activity of NADPH-cytochrome c reductase and cytochrome P-450 concentration in microsomes of rats treated in vivo with these compounds alone, or in the presence of phenobarbitone. The results showed that banol reduced the NADPH-cytochrome c reductase activity and the concentration of cytochrome P-450, while paraoxon reduced the activity of NADPH-cytochrome c reductase, but increased the cytochrome P-450 concentration. Phenobarbitone stimulated an increased NADPH-cytochrome c reductase activity and cytochrome P-450 concentration. When applied with banol and paraoxon, phenobarbitone lowered their inhibitory effect.
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