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. 1977 Oct;18(4):472-7.
doi: 10.1007/BF01683719.

The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats

N K Neskovic, S L Vitorovic

The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats

N K Neskovic et al. Bull Environ Contam Toxicol. 1977 Oct.

Abstract

We investigated the effect of banol and paraoxon on the activity of NADPH-cytochrome c reductase and cytochrome P-450 concentration in microsomes of rats treated in vivo with these compounds alone, or in the presence of phenobarbitone. The results showed that banol reduced the NADPH-cytochrome c reductase activity and the concentration of cytochrome P-450, while paraoxon reduced the activity of NADPH-cytochrome c reductase, but increased the cytochrome P-450 concentration. Phenobarbitone stimulated an increased NADPH-cytochrome c reductase activity and cytochrome P-450 concentration. When applied with banol and paraoxon, phenobarbitone lowered their inhibitory effect.

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