Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Oct 9;12(10):1361.
doi: 10.3390/children12101361.

Comment on Paditz et al. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children 2025, 12, 648

Paul Gringras  1 , Beth A Malow  2 , Carmen M Schröder  3   4   5   6
Affiliations
Comment

Comment on Paditz et al. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children 2025, 12, 648

Paul Gringras et al. Children (Basel). .

Abstract

We are writing in response to the recently published article, "The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review" by Paditz et al [...].

PubMed Disclaimer

Conflict of interest statement

Paul Gringras; Consultant Takeda; AGB Pharma; Eisai; Neurim Pharmaceuticals. Beth Malow: Consultant: Neurim Pharmaceuticals. Carmen Schroeder: Consultant: Neurim, Biocodex. Honoraria: Neurim, Biocodex, Janssen, InfectoPharm, Takeda, Medice.

Comment on

References

    1. Paditz E., Renner B., Koch R., Schneider B.M., Schlarb A.A., Ipsiroglu O.S. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children. 2025;12:648. doi: 10.3390/children12050648. - DOI - PMC - PubMed
    1. Garstang J., Wallis M. Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child Care Health Dev. 2006;32:585–589. doi: 10.1111/j.1365-2214.2006.00616.x. - DOI - PubMed
    1. Wright B., Sims D., Smart S., Alwazeer A., Alderson-Day B., Allgar V., Whitton C., Tomlinson H., Bennett S., Jardine J., et al. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: A randomised controlled crossover trial. J. Autism Dev. Disord. 2011;41:175–184. doi: 10.1007/s10803-010-1036-5. - DOI - PubMed
    1. Hayashi M., Mishima K., Fukumizu M., Takahashi H., Ishikawa Y., Hamada I., Sugioka H., Yotsuya O., Yamashita Y. Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. J. Autism Dev. Disord. 2022;52:2784–2793. doi: 10.1007/s10803-021-05139-w. - DOI - PubMed
    1. Tse A.C.Y., Lee P.H., Lau E.Y.Y., Cheng J.C.H., Ho A.W.Y., Lai E.W.H. Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders. PLoS ONE. 2022;17:e0270428. doi: 10.1371/journal.pone.0270428. - DOI - PMC - PubMed

LinkOut - more resources