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Comment
. 2025 Oct 9;12(10):1362.
doi: 10.3390/children12101362.

Reply to Gringras et al. Comment on "Paditz et al. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children 2025, 12, 648"

Ekkehart Paditz  1 , Bertold Renner  2 , Rainer Koch  3 , Barbara M Schneider  4 , Angelika A Schlarb  5
Affiliations
Comment

Reply to Gringras et al. Comment on "Paditz et al. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children 2025, 12, 648"

Ekkehart Paditz et al. Children (Basel). .

Abstract

We sincerely thank Drs [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Heterogeneity of the quality of studies available to date. Heterogeneity of the quality of existing randomized studies on neurogenetic disorders, ADHD, and ASD [8]. The limitations of the studies by Gringras et al. 2012 [5] and Appleton et al. 2012 [6] have been explicitly pointed out. Van Maanen, et al. (2017) [27], Schroder, et al. (2019) [28] and [16,29,30,31,32,33,34,35].
See this image and copyright information in PMC

References

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    1. Paditz E., Renner B., Koch R., Schneider B.M., Schlarb A.A., Ipsiroglu O.S. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review. Children. 2025;12:648. doi: 10.3390/children12050648. - DOI - PMC - PubMed
    1. de Souza A.L.D.M., Giacheti C.M., Do Couto M.C.H., Galina Spilla C.S., da Silva N.C., Proença M., Pinato L. Sleep disturbance in children with attention-deficit hyperactivity disorder: Relationship with melatonin and behavior. Neurol. Res. 2024;46:803–811. doi: 10.1080/01616412.2024.2359261. - DOI - PubMed
    1. Kanney M.L., Durmer J.S., Trotti L.M., Leu R. Rethinking bedtime resistance in children with autism: Is restless legs syndrome to blame? J. Clin. Sleep Med. 2020;16:2029–2035. doi: 10.5664/jcsm.8756. - DOI - PMC - PubMed
    1. Gringras P., Gamble C., Jones A.P., Wiggs L., Williamson P.R., Sutcliffe A., Montgomery P., Whitehouse W.P., Choonara I., Allport T., et al. Melatonin for sleep problems in children with neurodevelopmental disorders: Randomised double masked placebo controlled trial. BMJ (Clin. Res. Ed.) 2012;345:e6664. doi: 10.1136/bmj.e6664. - DOI - PMC - PubMed

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