Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Oct 12;12(10):1377.
doi: 10.3390/children12101377.

Managing Cough in Pediatric Neuromuscular Disorders: Lung Function and Care Strategies

Affiliations
Review

Managing Cough in Pediatric Neuromuscular Disorders: Lung Function and Care Strategies

Simone Foti Randazzese et al. Children (Basel). .

Abstract

Children with neuromuscular disorders (NMDs) are at high risk for respiratory complications due to impaired cough and weakness of respiratory muscles. Effective cough is essential for airway clearance, infections' prevention, and maintaining lung function. This narrative review explores the physiology of cough, the consequences of cough insufficiency, and methods for assessing respiratory function in pediatric NMDs. It discusses current care strategies including airway clearance techniques, respiratory muscle training, and preventive and supportive interventions. Emphasis is placed on multidisciplinary management and early intervention to improve outcomes and quality of life.

Keywords: care strategies; cough; lung function; neuromuscular disorders; pediatrics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Respiratory complications of ineffective cough in NMDs.
Figure 2
Figure 2
Key clinical signs and functional assessments of cough insufficiency in children with NMDs.
Figure 3
Figure 3
Main strategies for managing cough insufficiency in pediatric NMDs.

References

    1. Dabaj I., Ducatez F., Marret S., Bekri S., Tebani A. Neuromuscular disorders in the omics era. Clin. Chim. Acta. 2024;553:117691. doi: 10.1016/j.cca.2023.117691. - DOI - PubMed
    1. Dowling J.J., Gonorazky H.D., Cohn R.D., Campbell C. Treating pediatric neuromuscular disorders: The future is now. Am. J. Med. Genet. A. 2018;176:804–841. doi: 10.1002/ajmg.a.38418. - DOI - PMC - PubMed
    1. Bhai S.F., Vissing J. Diagnosis and management of metabolic myopathies. Muscle Nerve. 2023;68:250–256. doi: 10.1002/mus.27840. - DOI - PubMed
    1. Ahmed S.T., Craven L., Russell O.M., Turnbull D.M., Vincent A.E. Diagnosis and Treatment of Mitochondrial Myopathies. Neurotherapeutics. 2018;15:943–953. doi: 10.1007/s13311-018-00674-4. - DOI - PMC - PubMed
    1. Rathore G., Kang P.B. Pediatric Neuromuscular Diseases. Pediatr. Neurol. 2023;149:1–14. doi: 10.1016/j.pediatrneurol.2023.08.034. - DOI - PubMed

LinkOut - more resources