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Review
. 2025 Oct 11;13(10):2480.
doi: 10.3390/biomedicines13102480.

The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction-A Novel Biomarker in Patient Assessment

Cristian Sorin Prepeliuc  1   2 , Maria Antoanela Pasăre  1   3 , Maria Gabriela Grigoriu  1   3 , Ionela Larisa Miftode  3   4 , Radu Ștefan Miftode  5   6 , Andrei Vâță  3   4 , Irina Iuliana Costache-Enache  5   6 , Egidia Gabriela Miftode  3   4
Affiliations
Review

The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction-A Novel Biomarker in Patient Assessment

Cristian Sorin Prepeliuc et al. Biomedicines. .

Abstract

Sepsis represents a life-threatening organ dysfunction caused by a dysregulated host response to infection, and is considered a medical emergency. Therefore, quick diagnosis and treatment are required in order to improve survivability. Currently, patient evaluation in sepsis is based on the Sequential Organ Failure Assessment (SOFA) score to determine the severity of the disease; however, novel biomarkers are also actively researched with the aim to develop quicker diagnostic tools and better therapy. Endothelin-1 is one of the most potent vasoconstrictors found in the human body and is involved in the pathophysiology of both sepsis and other conditions involving organs that make up the SOFA score. In this narrative review, we aimed to gather information of this peptide's multiple effects and to help determine whether or not it could prove a valuable biomarker in the evaluation of patients with multi-organ dysfunction in sepsis.

Keywords: biomarker; cardiovascular dysfunction; endothelin receptor; endothelin-1; liver dysfunction; multi-organ dysfunction; neurological diseases; pulmonary dysfunction; renal dysfunction; sepsis.

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Conflict of interest statement

The authors declare no no conflict of interest.

Figures

Figure 1
Figure 1
Synthesis and receptors of Endothelin-1.
Figure 2
Figure 2
Effects of endothelin receptors.
Figure 3
Figure 3
ET-1 effects on the endothelium during sepsis.
See this image and copyright information in PMC

References

    1. Zhu J., Song C., Cai T., Yi L., Zhang W., Zhong J., Shen M. The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure. Cardiol. Res. Pract. 2022;2022:8570486. doi: 10.1155/2022/8570486. - DOI - PMC - PubMed
    1. Prepeliuc C.S., Miftode I.L., Pasare M.A., Miftode R.S., Stamateanu L.O., Costache I.I., Costache A.D., Miftode E. The search for novel biomarkers in sepsis-induced cardiomyopathy—A new challenge to overcome. Rom. J. Pharm. Pract. 2022;15:94–99. doi: 10.37897/RJPhP.2022.3.3. - DOI
    1. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415. doi: 10.1038/332411a0. - DOI - PubMed
    1. Banecki K.M.R.M., Dora K.A. Endothelin-1 in Health and Disease. Int. J. Mol. Sci. 2023;24:11295. doi: 10.3390/ijms241411295. - DOI - PMC - PubMed
    1. Kanai S.M., Clouthier D.E. Endothelin signaling in development. Development. 2023;150:dev201786. doi: 10.1242/dev.201786. - DOI - PMC - PubMed

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