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Review
. 2025 Nov 26;13(46):14967-14981.
doi: 10.1039/d5tb01944c.

Artificial intelligence-enabled hydrogels: innovations and applications

Affiliations
Review

Artificial intelligence-enabled hydrogels: innovations and applications

Shenhong Zhang et al. J Mater Chem B. .

Abstract

Due to the excellent biocompatibility and adjustability, hydrogels have broadened their application in different fields, such as 3D printing, tissue engineering, drug delivery, and biosensing. However, traditional hydrogel research is confronted with low screening efficiency and insufficient design and characterization methods. In recent years, artificial intelligence (AI) has become a revolutionary tool for hydrogel research. AI technologies such as machine learning and deep learning have driven hydrogels towards intelligence and functionality. This article reviews the innovations of AI in the design and performance optimization of hydrogels, as well as their multi-scenario applications, such as 3D printing, environmental detection, and wound healing. Finally, the limitations, challenges and strategies for AI-driven hydrogel research are discussed. In conclusion, the cross-integration of AI and hydrogels has become an important trend of scientific research, providing new tools for the research of new hydrogel materials.

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