In vitro characterization of drynaria in-situ gel: A novel approach to periodontal disease management

Abstract

The condition of periodontal diseases that results from oral dysbiosis-related inflammation poses crucial public health concerns. Therefore, it is of interest to assess an in-situ gel made with Drynaria rhizome extract for local drug application in periodontal care. The drynaria in-situ gel has desirable clinical properties because its combination of Sodium Tripolyphosphate (STPP), Poloxamer 407, Acetic Acid and Chitosan produces temperature-sensitive features and viscosity stability. Studies under laboratory conditions proved both the uniformity and stability of the gel. The tested Drynaria gel emerges as a promising choice for local drug delivery in periodontal healthcare and researchers need to conduct additional clinical trials to prove its performance in real-world conditions.

Keywords: drynaria in-situ gel; evaluation; periodontal diseases.