Conflict of Interest Disclosures: Dr Knowles reported serving on the medical and scientific advisory boards of the SynGAP Research Fund and the Lennox-Gastaut Syndrome Foundation, and on the executive board of the Pediatric Epilepsy Research Consortium outside the submitted work. Dr Hewitt reported receiving support from University of Rochester Waasdorp Pediatric Neurology Endowment Fund outside the submitted work. Dr Sahin reported receiving grants from the National Institutes of Health/National Institute of Child Health and Human Development (grant P50HD105351), Novartis, Biogen, Astellas, Aeovian, Bridgebio, and Aucta; and serving on scientific advisory boards for Novartis, Roche, Regenxbio, SpringWorks Therapeutics, Jaguar Therapeutics, and Alkermes outside the submitted work. Dr Gelineau-Morel reported receiving grant support from the Pediatric Epilepsy Research Foundation and being a consultant for Vima Therapeutics outside the submitted work. Dr Shellhaas reported receiving grants from the National Institutes of Health, royalties from UpToDate for authorship of topics related to neonatal seizures, consultant fees from the Epilepsy Study Consortium, and a stipend for her role as president of the Pediatric Epilepsy Research Foundation outside the submitted work. Dr Bonkowsky reported receiving grant support from ELA; being involved in clinical trials with Calico, SwanBio, and Minoryx; receiving royalties from Manson Publishing and BioFire; writing content for UpToDate; and serving as a consultant for Calico, Denali, Neurogene, Passage Bio, and Ionis outside the submitted work. No other disclosures were reported.