doi: 10.1128/JVI.10.4.653-657.1972.
Isolation of temperature-sensitive mutants of murine sarcoma virus
- PMID: 4117345
- PMCID: PMC356516
- DOI: 10.1128/JVI.10.4.653-657.1972
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Isolation of temperature-sensitive mutants of murine sarcoma virus
J Virol.
1972 Oct.
Abstract
Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.
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