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. 1972 Oct;10(4):653-7.
doi: 10.1128/JVI.10.4.653-657.1972.

Isolation of temperature-sensitive mutants of murine sarcoma virus

E M Scolnick, J R Stephenson, S A Aaronson

Isolation of temperature-sensitive mutants of murine sarcoma virus

E M Scolnick et al. J Virol. 1972 Oct.

Abstract

Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.

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References

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