doi: 10.1128/jb.112.3.1184-1192.1972.
Polycistronic effects of catabolite repression on the lac operon
- PMID: 4118294
- PMCID: PMC251547
- DOI: 10.1128/jb.112.3.1184-1192.1972
Item in Clipboard
Polycistronic effects of catabolite repression on the lac operon
J Bacteriol.
1972 Dec.
Abstract
The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively. We find that both cistrons are affected coordinately by this form of repression. We also find that a single alteration at the lac promoter region is sufficient to abolish sensitivity to repression of both cistrons. From this, we conclude that there is only one target site for catabolite repression in the lac operon.
Similar articles
-
Residual polarity and transcription-translation coupling during recovery from chloramphenicol or fusidic acid.J Bacteriol. 1974 Feb;117(2):631-40. doi: 10.1128/jb.117.2.631-640.1974. J Bacteriol. 1974. PMID: 4359650 Free PMC article.
-
Catabolite repression of the lac operon. Separt epressionof two enzymes.Biochem J. 1969 Sep;114(2):313-9. doi: 10.1042/bj1140313. Biochem J. 1969. PMID: 4897463 Free PMC article.
-
A mutant of Escherichia coli with a new, highly efficient promoter for the lactose operon.Proc Natl Acad Sci U S A. 1973 Dec;70(12):3693-7. doi: 10.1073/pnas.70.12.3693. Proc Natl Acad Sci U S A. 1973. PMID: 4590169 Free PMC article.
-
Regulation of gene expression in Escherichia coli by cyclic AMP.Recent Prog Horm Res. 1971;27:421-32. doi: 10.1016/b978-0-12-571127-2.50034-1. Recent Prog Horm Res. 1971. PMID: 4336400 Review. No abstract available.
-
[Regulation of enzyme synthesis by catabolic repression with participation of adenosine-3',5'-cyclomonophosphate in microorganisms].Izv Akad Nauk SSSR Biol. 1977 Mar-Apr;(2):209-18. Izv Akad Nauk SSSR Biol. 1977. PMID: 195989 Review. Russian. No abstract available.
Cited by
-
Mutations in the L-arabinose operon of Escherichia coli B-r that result in hypersensitivity to catabolite repression.J Bacteriol. 1974 Feb;117(2):417-21. doi: 10.1128/jb.117.2.417-421.1974. J Bacteriol. 1974. PMID: 4359644 Free PMC article.
-
Inhibition of lacZ gene translation initiation in trp-lac fusion strains.J Bacteriol. 1974 Mar;117(3):1231-9. doi: 10.1128/jb.117.3.1231-1239.1974. J Bacteriol. 1974. PMID: 4591949 Free PMC article.
-
Catabolite translational effects on the lac messenger RNA of Escherichia coli K12.Mol Gen Genet. 1976 Oct 18;148(1):99-104. doi: 10.1007/BF00268550. Mol Gen Genet. 1976. PMID: 792685
-
Transient repression of catabolite-sensitive enzyme synthesis elicited by 2,4-dinitrophenol.J Bacteriol. 1975 Sep;123(3):815-23. doi: 10.1128/jb.123.3.815-823.1975. J Bacteriol. 1975. PMID: 169228 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
