Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Dec;9(12):807-808.
doi: 10.1038/s41570-025-00772-w.

Small but powerful

Andrew V Stachulski  1 , Christopher J Schofield  2
Affiliations

Small but powerful

Andrew V Stachulski et al. Nat Rev Chem. 2025 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: A.V. S. was an employee of Beecham Pharmaceuticals, later Smith Kline Beecham, 1978–1991. C.J.S. declares no competing interests.

References

    1. Fleming, A. On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. Br. J. Exp. Pathol. 10, 226–236 (1929). - PMC
    1. Howarth, T. T., Brown, A. G. & King, T. J. Clavulanic acid, a novel β-lactam isolated from Streptomyces clavuligerus; X-ray crystal structure analysis. J. Chem. Soc. Chem. Commun. 266–267 (1976).
    1. Brown, A. G. et al. Naturally occurring β-lactamase inhibitors with antibacterial activity. J. Antibiot. 29, 668–669 (1976).
    1. Abraham, E. & Chain, E. An enzyme from bacteria able to destroy penicillin. Nature 146, 837 (1940).
    1. Reading, C. & Cole, M. Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob. Agents Chemother. 11, 852–857 (1977). - PubMed - PMC

LinkOut - more resources