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. 1972 Dec;10(6):1231-5.
doi: 10.1128/JVI.10.6.1231-1235.1972.

The glycoprotein of vesicular stomatitis virus is the antigen that gives rise to and reacts with neutralizing antibody

J M Kelley, S U Emerson, R R Wagner

The glycoprotein of vesicular stomatitis virus is the antigen that gives rise to and reacts with neutralizing antibody

J M Kelley et al. J Virol. 1972 Dec.

Abstract

The glycoprotein, but no other virion protein, of vesicular stomatitis virus was solubilized by the nonionic detergent Triton X-100 in low ionic strength buffer. The solubilized viral glycoprotein induced the synthesis of antibody that formed a single precipitin line with the glycoprotein and that neutralized the infectivity of the virus. The neutralizing activity of the antibody was efficiently blocked by purified glycoprotein.

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