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. 1972 Dec;69(12):3820-4.
doi: 10.1073/pnas.69.12.3820.

Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine

A M Wu, R C Ting, M Paran, R C Gallo

Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine

A M Wu et al. Proc Natl Acad Sci U S A. 1972 Dec.

Abstract

Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.

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References

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