Atopic Dermatitis (AD) Related Cord Blood DNA Methylation Patterns Are Linked to Maternal AD

Laura Matzner¹, Johanna Denkena², Marey Messingschlager¹, Anke Seegebarth¹, Rosa Engelhardt¹, Zhuoxin Peng³, Parastoo Kheiroddin⁴, Sebastian D Mackowiak², Hermann Brenner⁵, Dietrich Rothenbacher^{6

7}, Naveed Ishaque², Michael Kabesch^{4

8}, Roland Eils^{2

9

10

11}, Jon Genuneit^{3

12}, Saskia Trump^{1

9}, Irina Lehmann^{1

9

10

11}

Affiliations

¹ Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Center of Digital Health, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.
³ Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
⁴ University Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Regensburg, Germany.
⁵ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
⁷ German Center of Child and Adolescent Health (DZKJ) Partner Site, Ulm, Germany.
⁸ Member of the Research and Development Campus Regensburg (WECARE) at the Clinic St. Hedwig, Regensburg, Germany.
⁹ German Center of Child and Adolescent Health (DZKJ) Partner Site, Berlin, Germany.
¹⁰ German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.
¹¹ Intelligent Medicine Institute, Fudan University, Shanghai, China.
¹² German Center of Child and Adolescent Health (DZKJ) Partner Site, Leipzig, Germany.

Laura Matzner et al. Allergy. 2025.

. 2025 Nov 4.

doi: 10.1111/all.70130. Online ahead of print.

¹ Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Center of Digital Health, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.
³ Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
⁴ University Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Regensburg, Germany.
⁵ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
⁷ German Center of Child and Adolescent Health (DZKJ) Partner Site, Ulm, Germany.
⁸ Member of the Research and Development Campus Regensburg (WECARE) at the Clinic St. Hedwig, Regensburg, Germany.
⁹ German Center of Child and Adolescent Health (DZKJ) Partner Site, Berlin, Germany.
¹⁰ German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.
¹¹ Intelligent Medicine Institute, Fudan University, Shanghai, China.
¹² German Center of Child and Adolescent Health (DZKJ) Partner Site, Leipzig, Germany.

No abstract available

Keywords: atopic dermatitis; epidemiology; epigenetics; pediatrics.

Publication types