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. 2025 Dec;11(4):248-251.
doi: 10.1159/000548277. Epub 2025 Sep 5.

Uveal Melanomas Masquerading as Inflammatory Lesions

Malcolm Wiseman Jr  1 , Timothy Fuller  2 , R Nick Hogan  3   4 , J William Harbour  3   5 , Noy Ashkenazy  3
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Free PMC article

Uveal Melanomas Masquerading as Inflammatory Lesions

Malcolm Wiseman Jr et al. Ocul Oncol Pathol. 2025 Dec.
Free PMC article

Abstract

Introduction: Most uveal melanomas (UMs) are readily diagnosed based on their characteristic features, but they can occasionally pose a diagnostic challenge, such as when they present as an inflammatory mass. We present 2 patients who presented with an intraocular mass that was initially diagnosed as an inflammatory or infectious process and subsequently found to represent a UM.

Case presentations: Two cases of UM masquerading as uveitis are described.

Conclusion: UM should be considered in the differential diagnosis of an intraocular inflammatory mass. Diagnosis may require tumor biopsy.

Keywords: Case report; Inflammation; Melanoma; PRAME; Uvea; Uveitis.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: none (M.W., N.A., T.F., and R.N.H.); Castle Biosciences (J.W.H.).

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