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. 1973 Jan;70(1):235-9.
doi: 10.1073/pnas.70.1.235.

Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody

D Carson, M Weigert

Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody

D Carson et al. Proc Natl Acad Sci U S A. 1973 Jan.

Abstract

The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.

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References

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