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. 1973 Jan;24(1):67-76.

Common antigen structures of HL-A antigens. I. Antigenic determinants recognizable by rabbits on papain-solubilized HL-A molecular fragments

Y Miyakawa, N Tanigaki, Y Yagi, D Pressman

Common antigen structures of HL-A antigens. I. Antigenic determinants recognizable by rabbits on papain-solubilized HL-A molecular fragments

Y Miyakawa et al. Immunology. 1973 Jan.

Abstract

Antigenic determinants recognizable by rabbits were found to be present on the molecular fragments (48,000 Daltons) which were obtained by papain-solubilization of the membrane fractions of cultured human lymphoid cells and which carried the HL-A determinants. Results were obtained which suggest that these antigenic determinants are present in common on these molecular fragments carrying HL-A determinants regardless of their HL-A specificity and are restricted to the molecular fragments which carry HL-A determinants.

The study was made by use of radioimmune methods involving the binding of radioiodine-labelled soluble HL-A antigen preparations by anti-HL-A alloantisera and by rabbit antisera raised against the membrane fractions of cultured human lymphoid cells.

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