Safety of high dose bedaquiline treatment in extensively drug-resistant (XDR)-TB patients

Manuel Peterka¹, David Krieger¹, Elham Khatamzas^{2

3}, Claudia Denkinger^{2

3}, Niklas Köhler^{4

5}, Chrsitoph Lange^{4

6

7}, Martin Macholz⁸, Christoph Lübbert⁸, Simon Daller⁹, Michael Knappik⁹, Martin Kuhns¹⁰, Brit Häcker¹¹, Silke Polsfuß¹², Torsten Bauer^{1

11}, Ralf Otto-Knapp¹³

Affiliations

¹ Helios Clinic Emil von Behring, Department of Pneumology, Chest Hospital Heckeshorn, Berlin, Germany.
² Department of Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
³ German Center for Infection Research (DZIF), Partner Site Heidelberg, University Hospital, Heidelberg, Germany.
⁴ Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
⁵ Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany.
⁶ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Germany.
⁷ Baylor College of Medicine and Texas Childreńs Hospital, Houston, Texas, USA.
⁸ Department of Infectious Diseases and Tropical Medicine, Hospital St. Georg, Leipzig, Germany.
⁹ Department for Respiratory Diseases, Site Penzing of Clinic Ottakring, Vienna, Austria.
¹⁰ National Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
¹¹ German Central Committee against Tuberculosis, Berlin, Germany.
¹² Institute for Microbiology, Immunology and Laboratory Medicine, Medical Care Center at the Helios Klinikum Emil von Behring, Berlin.
¹³ German Central Committee against Tuberculosis, Berlin, Germany rotto-knapp@dzk-tuberkulose.de.

Manuel Peterka et al. Eur Respir J. 2025.

. 2025 Nov 6:2501496.

doi: 10.1183/13993003.01496-2025. Online ahead of print.

¹ Helios Clinic Emil von Behring, Department of Pneumology, Chest Hospital Heckeshorn, Berlin, Germany.
² Department of Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
³ German Center for Infection Research (DZIF), Partner Site Heidelberg, University Hospital, Heidelberg, Germany.
⁴ Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
⁵ Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany.
⁶ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Germany.
⁷ Baylor College of Medicine and Texas Childreńs Hospital, Houston, Texas, USA.
⁸ Department of Infectious Diseases and Tropical Medicine, Hospital St. Georg, Leipzig, Germany.
⁹ Department for Respiratory Diseases, Site Penzing of Clinic Ottakring, Vienna, Austria.
¹⁰ National Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
¹¹ German Central Committee against Tuberculosis, Berlin, Germany.
¹² Institute for Microbiology, Immunology and Laboratory Medicine, Medical Care Center at the Helios Klinikum Emil von Behring, Berlin.
¹³ German Central Committee against Tuberculosis, Berlin, Germany rotto-knapp@dzk-tuberkulose.de.

No abstract available

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