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Review
. 2025 Aug 21:56:101371.
doi: 10.1016/j.lanepe.2025.101371. eCollection 2025 Sep.

Reducing inequalities in cardiovascular disease: focus on marginalized populations considering ethnicity and race

Affiliations
Review

Reducing inequalities in cardiovascular disease: focus on marginalized populations considering ethnicity and race

Sonia S Anand et al. Lancet Reg Health Eur. .

Abstract

Cardiovascular disease (CVD) and its risk factors are more prevalent among traditionally marginalized racial, ethnic, and Indigenous groups. These populations also often face greater barriers to accessing cardiovascular health care, further contributing to the health equity gap. To address the challenge of inequalities and disparities in cardiovascular health outcomes, the Lancet Regional Health-Europe convened experts to evaluate the current state of knowledge on inequalities and disparities in cardiovascular health among marginalized populations and propose recommendations to address these disparities. This Series paper aims to review disparities in CVD referring to coronary heart disease and stroke, based on race, ethnicity, ancestry, and Indigeneity emphasizing the intersection of these factors with sex, gender, and socioeconomic status (SES) across Europe and North America. These regions were chosen as they have well established health-care systems, with persistent, and in some regions widening, disparities in cardiovascular health and outcomes. Ethnicity and race should be measured in a standardized manner in health-care administrative databases to identify high risk groups who might need focused programmes to improve health-care access and to address bias and inequities in care. Strategies that policymakers, health-care professionals, and advocacy groups can use to advance cardiovascular health equity include improving access to health-care systems and research for high-risk communities, fostering trust between these communities and public health providers, and enhancing the delivery of evidence-based therapies for the prevention and treatment of CVD.

Keywords: Cardiovascular disease; Ethnicity; Health equity; Race.

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Conflict of interest statement

SSA holds the Heart and Stroke Foundation Michael G DeGroote Chair in Population Health, a Canada Research Chair in Ethnic Diversity and Cardiovascular Disease. Dr. Anand has received speaking fees from Novartis, Novo Nordisk, and Amgen in the past year. MM is the recipient of the Canadian Cardiovascular Society/Pfizer/Canadian Heart Function Alliance Research Fellowship in First Nations, Inuit, and Métis Communities Experiencing Heart Failure Inequities. MM has received speaking honoraria from Bristol Myers Squibb. MG is supported by contracts from the National Heart, Lung, and Blood Institutes nos. N01-HV-068161, N01-HV-068162, N01-HV-068163, N01-HV-068164, grants U01 HL064829, U01 HL649141, U01 HL649241, K23 HL105787, K23 HL125941, K23 HL127262, K23HL151867, T32 HL069751, R01 HL090957, R03 AG032631, R01 HL146158, R01 HL146158-04S1, R01 HL124649, R01 HL153500, U54 AG065141, General Clinical Research Center grant MO1-RR00425 from the National Center for Research Resources, the National Center for Advancing Translational Sciences Grant UL1TR000124, Department of Defense grant PR161603 (CDMRP-DoD), and grants from the Gustavus and Louis Pfeiffer Research Foundation, Danville, NJ, The Women's Guild of Cedars-Sinai Medical Center, Los Angeles, CA, The Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA, and QMED, Inc., Laurence Harbor, NJ, the Edythe L. Broad and the Constance Austin Women's Heart Research Fellowships, Cedars-Sinai Medical Center, Los Angeles, CA, the Barbra Streisand Women's Cardiovascular Research and Education Program, Cedars-Sinai Medical Center, Los Angeles, CA, The Society for Women's Health Research, Washington, D.C., the Linda Joy Pollin Women's Heart Health Program, the Erika Glazer Women's Heart Health Project, the Adelson Family Foundation, Cedars-Sinai Medical Center, Los Angeles, CA, Robert NA. Winn Diversity in Clinical Trials Career Development Award (Winn CDA) and the Anita Dann Friedman Endowment in Women's Cardiovascular Medicine & Research. This work is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute, the National Institutes of Health, or the U.S. Department of Health and Human Services. Consultant Fees/Honoraria: Esperion, Medtronic Inc, unrelated to this work. JD has received CME honoraria and/or consulting fees from Aegerion, Amgen, Astrazeneca, Bayer, Boehringer Ingelheim, Merck, Novartis, Novo Nordisk, Pfizer, Sanofi, Takeda. Research grants from British Heart Foundation, MRC(UK), NIHR, PHE, MSD, Pfizer, Aegerion, Colgate, Roche. He is a member of the Study Steering Committees for Novo Nordisk (SOUL and SELECT). AAQ has been supported by NIH grants P01HL154996-01A1, R33HL138657-05, 5T32 HL130025, P30DK111024-07S2, R01HL166004-01, 5R01HL158141-043, 3R01HL157311-03S1, 1R01HL166004-01.

Figures

Fig. 1
Fig. 1
Framework for understanding inequalities and disparities in cardiovascular health for marginalized populations. Conceptual framework illustrates multifaceted and intersecting determinants contributing to inequalities in cardiovascular health among disadvantaged populations. Cardiovascular health is positioned at the center, as the primary outcome of interest, while genetics, sociopolitical context, health access, environment, and ancestry are depicted as key influencing domains. Circular connections between domains signify mutual influence rather than unidirectional relationship. Dashed arrows represent indirect influences, while solid arrows indicate contributing factors extending from the conceptual model. This emphasizes that various structural and environmental determinants shape cardiovascular health and not a directional effect away from health.
Fig. 2
Fig. 2
Innovative solutions to improve health disparities. Figure presents patient-centered, culturally sensitive solutions aimed at increasing health equity. Blue boxes represent broad solution categories; white boxes outline specific interventions within each category. While all proposed interventions aim to reduce health disparities—including cardiovascular disease—some may be more impactful depending on context. The basis for these interventions stems from expert recommendations, policy initiatives, and published consensus guidelines.

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