doi: 10.1111/cea.70173.
Online ahead of print.
Assessment of the Effectiveness of Allergic Rhinitis Medications Using a Target Trial Emulation Approach Based on Mobile Health Data
Nuno Lourenço-Silva
1
2
, Bernardo Sousa-Pinto
1
2
, Antonio Bognanni
3
4
, Matteo Martini
5
6
, Michal Ordak
7
, Giovanni Paoletti
8
9
, Sara Gil-Mata
1
2
, Rita Amaral
1
2
10
11
, Anna Bedbrook
12
13
, Patrizia Bonadonna
14
, Luisa Brussino
15
16
, G Walter Canonica
8
9
, João Coutinho-Almeida
1
2
, Alvaro A Cruz
17
, Wienczyslawa Czarlewski
12
13
18
, Mark Dykewicz
19
, Mattia Giovannini
20
21
, Bilun Gemicioglu
22
23
, Juan Carlos Ivancevich
24
, Ludger Klimek
25
26
, Violeta Kvedariene
27
28
, Desiree E Larenas-Linnemann
29
, Manuel Marques-Cruz
1
2
, André Moreira
30
31
32
, Marek Niedoszytko
33
, Ana Margarida Pereira
1
2
34
, Nikolaos G Papadopoulos
35
, Nhân Pham-Thi
36
37
38
, Frederico S Regateiro
39
40
41
42
, Sanna K Toppila-Salmi
43
44
, Boleslaw Samolinski
45
, Joaquin Sastre
46
, Luís Taborda-Barata
47
48
, Tuuli Thomander
1
49
, Ilgım Vardaloğlu Koyuncu
50
, Arunas Valiulis
51
52
, Leticia de Las Vecillas
53
, Maria Teresa Ventura
54
55
, Jolanta Walusiak-Skorupa
56
, Yi-Kui Xiang
57
58
59
, Oliver Pfaar
60
, João A Fonseca
1
2
, Torsten Zuberbier
57
58
, Holger J Schünemann
3
4
58
, Danilo di Bona
61
, Jean Bousquet
57
58
, Rafael José Vieira
1
2
Affiliations
Affiliations
- 1 MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
- 2 CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
- 3 Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
- 4 Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.
- 5 Department of Internal Medicine, Allergy Unit, University Hospital AOU Delle Marche, Ancona, Italy.
- 6 Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
- 7 Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
- 8 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
- 9 Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy.
- 10 Department of Cardiovascular and Respiratory Sciences, Porto Health School, Polytechnic Institute of Porto, Porto, Portugal.
- 11 Department of Women's and Children's Health, Paediatric Research, Uppsala University, Uppsala, Sweden.
- 12 Aria, Montpellier, France.
- 13 MASK-Air, Montpellier, France.
- 14 Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
- 15 Department of Medical Sciences, University of Torino, Torino, Italy.
- 16 Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.
- 17 Fundacao ProAR and (Faculdade de Medicina da) Universidade Federal da Bahia, Salvador, Bahia, Brazil.
- 18 Medical Consulting Czarlewski, Levallois-Perret, France.
- 19 Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
- 20 Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
- 21 Department of Health Sciences, University of Florence, Florence, Italy.
- 22 Department of Pulmonary Diseases, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
- 23 Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
- 24 Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
- 25 Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
- 26 Center for Rhinology and Allergology, Wiesbaden, Germany.
- 27 Clinic of Chest Diseases and Allergology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
- 28 Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
- 29 Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
- 30 EPIUnit-Institute of Public Health, University of Porto, and Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
- 31 Serviço de Imunoalergologia, Centro Hospitalar Universitário São João, Porto, Portugal.
- 32 Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
- 33 Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
- 34 Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.
- 35 Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
- 36 Ecole Polytechnique de Palaiseau, Palaiseau, France.
- 37 IRBA (Institut de Recherche Bio-Médicale Des Armées), Bretigny Sur Orge, France.
- 38 Université Paris Cité, Paris, France.
- 39 Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
- 40 Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
- 41 Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
- 42 UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
- 43 Department of Otorhinolaryngology, University of Eastern Finland and the North Savo Wellbeing Services County, Kuopio, Finland.
- 44 Department of Allergy, Skin and Allergy Hospital, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
- 45 Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
- 46 Allergy Service, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, CIBERES-ISCIII, Madrid, Spain.
- 47 RISE-Health, Faculty of Health Sciences, and UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
- 48 Department of Immunoallergology, Cova da Beira Local Health Unit, Covilhã, Portugal.
- 49 The Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 50 Bagcilar Training and Research Hospital, Department of Chest Diseases, Istanbul, Turkey.
- 51 Clinic of Asthma, Allergy and Chronic Lung Diseases, Vilnius, Lithuania.
- 52 Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
- 53 Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
- 54 University of Bari Medical School, Bari, Italy.
- 55 Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy.
- 56 Department of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.
- 57 Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
- 58 Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
- 59 Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
- 60 Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
- 61 Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
- PMID: 41207877
- DOI: 10.1111/cea.70173
Item in Clipboard
Assessment of the Effectiveness of Allergic Rhinitis Medications Using a Target Trial Emulation Approach Based on Mobile Health Data
Nuno Lourenço-Silva et al.
Clin Exp Allergy.
.
Display options
Format
doi: 10.1111/cea.70173.
Online ahead of print.
Authors
Nuno Lourenço-Silva
1
2
, Bernardo Sousa-Pinto
1
2
, Antonio Bognanni
3
4
, Matteo Martini
5
6
, Michal Ordak
7
, Giovanni Paoletti
8
9
, Sara Gil-Mata
1
2
, Rita Amaral
1
2
10
11
, Anna Bedbrook
12
13
, Patrizia Bonadonna
14
, Luisa Brussino
15
16
, G Walter Canonica
8
9
, João Coutinho-Almeida
1
2
, Alvaro A Cruz
17
, Wienczyslawa Czarlewski
12
13
18
, Mark Dykewicz
19
, Mattia Giovannini
20
21
, Bilun Gemicioglu
22
23
, Juan Carlos Ivancevich
24
, Ludger Klimek
25
26
, Violeta Kvedariene
27
28
, Desiree E Larenas-Linnemann
29
, Manuel Marques-Cruz
1
2
, André Moreira
30
31
32
, Marek Niedoszytko
33
, Ana Margarida Pereira
1
2
34
, Nikolaos G Papadopoulos
35
, Nhân Pham-Thi
36
37
38
, Frederico S Regateiro
39
40
41
42
, Sanna K Toppila-Salmi
43
44
, Boleslaw Samolinski
45
, Joaquin Sastre
46
, Luís Taborda-Barata
47
48
, Tuuli Thomander
1
49
, Ilgım Vardaloğlu Koyuncu
50
, Arunas Valiulis
51
52
, Leticia de Las Vecillas
53
, Maria Teresa Ventura
54
55
, Jolanta Walusiak-Skorupa
56
, Yi-Kui Xiang
57
58
59
, Oliver Pfaar
60
, João A Fonseca
1
2
, Torsten Zuberbier
57
58
, Holger J Schünemann
3
4
58
, Danilo di Bona
61
, Jean Bousquet
57
58
, Rafael José Vieira
1
2
Affiliations
- 1 MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
- 2 CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
- 3 Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
- 4 Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.
- 5 Department of Internal Medicine, Allergy Unit, University Hospital AOU Delle Marche, Ancona, Italy.
- 6 Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
- 7 Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
- 8 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
- 9 Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy.
- 10 Department of Cardiovascular and Respiratory Sciences, Porto Health School, Polytechnic Institute of Porto, Porto, Portugal.
- 11 Department of Women's and Children's Health, Paediatric Research, Uppsala University, Uppsala, Sweden.
- 12 Aria, Montpellier, France.
- 13 MASK-Air, Montpellier, France.
- 14 Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
- 15 Department of Medical Sciences, University of Torino, Torino, Italy.
- 16 Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.
- 17 Fundacao ProAR and (Faculdade de Medicina da) Universidade Federal da Bahia, Salvador, Bahia, Brazil.
- 18 Medical Consulting Czarlewski, Levallois-Perret, France.
- 19 Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
- 20 Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
- 21 Department of Health Sciences, University of Florence, Florence, Italy.
- 22 Department of Pulmonary Diseases, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
- 23 Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
- 24 Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
- 25 Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
- 26 Center for Rhinology and Allergology, Wiesbaden, Germany.
- 27 Clinic of Chest Diseases and Allergology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
- 28 Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
- 29 Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
- 30 EPIUnit-Institute of Public Health, University of Porto, and Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
- 31 Serviço de Imunoalergologia, Centro Hospitalar Universitário São João, Porto, Portugal.
- 32 Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
- 33 Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
- 34 Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.
- 35 Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
- 36 Ecole Polytechnique de Palaiseau, Palaiseau, France.
- 37 IRBA (Institut de Recherche Bio-Médicale Des Armées), Bretigny Sur Orge, France.
- 38 Université Paris Cité, Paris, France.
- 39 Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
- 40 Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
- 41 Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
- 42 UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
- 43 Department of Otorhinolaryngology, University of Eastern Finland and the North Savo Wellbeing Services County, Kuopio, Finland.
- 44 Department of Allergy, Skin and Allergy Hospital, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
- 45 Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
- 46 Allergy Service, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, CIBERES-ISCIII, Madrid, Spain.
- 47 RISE-Health, Faculty of Health Sciences, and UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
- 48 Department of Immunoallergology, Cova da Beira Local Health Unit, Covilhã, Portugal.
- 49 The Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 50 Bagcilar Training and Research Hospital, Department of Chest Diseases, Istanbul, Turkey.
- 51 Clinic of Asthma, Allergy and Chronic Lung Diseases, Vilnius, Lithuania.
- 52 Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
- 53 Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
- 54 University of Bari Medical School, Bari, Italy.
- 55 Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy.
- 56 Department of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.
- 57 Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
- 58 Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
- 59 Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
- 60 Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
- 61 Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
- PMID: 41207877
- DOI: 10.1111/cea.70173
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