A double-blind, randomised placebo-controlled trial examining the effect of MitoQ on myocardial energetics in patients with dilated cardiomyopathy

Brian P Halliday^{1

2}, Ruth Owen^{3

4

5}, Aaraby Ragavan^{1

2}, Katherine L Smith^{1

2}, Ben Statton⁶, Alaine Berry⁶, Alex Kasiakogias², Zoi Tsoumani², Mayooran Shanmugnathan^{2

7}, Jason N Dungu⁸, Antonio de Marvao^{9

10}, Upasana Tayal^{1

2}, James S Ware^{1

2

6}, Declan P O'Regan⁶, Dudley J Pennell^{1

2}, John G F Cleland¹¹, Sanjay K Prasad^{1

2}, John Gregson³, Michael P Murphy^{12

13}, Oliver Rider⁷, Ladislav Valkovič^{7

14}

Affiliations

¹ National Heart and Lung Institute, Imperial College London, London, UK.
² Royal Brompton and Harefield Hospitals, part of Guy's and St Thomas' NHS Foundation Trust, London, UK.
³ London School of Hygiene and Tropical Medicine, London, UK.
⁴ Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
⁵ Oxon Epidemiology, Madrid, Spain.
⁶ Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.
⁷ Oxford Centre for Clinical MR Research (OCMR), Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
⁸ Basildon and Thurrock Hospitals NHS Foundation Trust, Essex, UK and Anglia Ruskin University, Essex, UK.
⁹ Guy's and St Thomas' NHS Foundation Trust, London, UK.
¹⁰ King's College London, London, UK.
¹¹ School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
¹² MRC Mitochondrial Biology Unit, University of Cambridge, UK.
¹³ Dept of Medicine, University of Cambridge, UK.
¹⁴ Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia.

Brian P Halliday et al. Eur Heart J Cardiovasc Imaging. 2025.

. 2025 Nov 10:jeaf310.

doi: 10.1093/ehjci/jeaf310. Online ahead of print.

¹ National Heart and Lung Institute, Imperial College London, London, UK.
² Royal Brompton and Harefield Hospitals, part of Guy's and St Thomas' NHS Foundation Trust, London, UK.
³ London School of Hygiene and Tropical Medicine, London, UK.
⁴ Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
⁵ Oxon Epidemiology, Madrid, Spain.
⁶ Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.
⁷ Oxford Centre for Clinical MR Research (OCMR), Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
⁸ Basildon and Thurrock Hospitals NHS Foundation Trust, Essex, UK and Anglia Ruskin University, Essex, UK.
⁹ Guy's and St Thomas' NHS Foundation Trust, London, UK.
¹⁰ King's College London, London, UK.
¹¹ School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
¹² MRC Mitochondrial Biology Unit, University of Cambridge, UK.
¹³ Dept of Medicine, University of Cambridge, UK.
¹⁴ Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia.

No abstract available

Keywords: Dilated cardiomyopathy; heart failure; mitochondrial dysfunction; oxidative stress.

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