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Practice Guideline
. 2025 Nov;23(11):426-436.
doi: 10.6004/jnccn.2025.0053.

NCCN Guidelines® Insights: Breast Cancer, Version 5.2025

William J Gradishar  1 , Meena S Moran  2 , Jame Abraham  3 , Vandana Abramson  4 , Rebecca Aft  5 , Doreen Agnese  6 , Kimberly H Allison  7 , Bethany Anderson  8 , Janet Bailey  9 , Harold J Burstein  10 , Nan Chen  11 , Helen Chew  12 , Chau Dang  13 , Anthony D Elias  14 , Sharon H Giordano  15 , Matthew P Goetz  16 , Rachel C Jankowitz  17 , Sara H Javid  18 , Jairam Krishnamurthy  19 , A Marilyn Leitch  20 , Janice Lyons  3 , Susie McCloskey  21 , Melissa McShane  22 , Joanne Mortimer  23 , Sameer A Patel  22 , Laura H Rosenberger  24 , Hope S Rugo  25 , Cesar A Santa-Maria  26 , Bryan P Schneider  27 , Mary Lou Smith  28 , Hatem Soliman  29 , Erica M Stringer-Reasor  30 , Melinda L Telli  7 , Mei Wei  31 , Kari B Wisinski  8 , Amulya Yellala  19 , Kay T Yeung  32 , Jessica S Young  33 , Ryan Schonfeld  34 , Rashmi Kumar  34
Affiliations
Practice Guideline

NCCN Guidelines® Insights: Breast Cancer, Version 5.2025

William J Gradishar et al. J Natl Compr Canc Netw. 2025 Nov.

Abstract

The treatment landscape of invasive early-stage and metastatic breast cancer is evolving constantly. These NCCN Guidelines Insights focus on recent updates included in the most recent version (version 5.2025) of the NCCN Guidelines for Breast Cancer specific to workup, locoregional therapy, surveillance, and systemic neoadjuvant/adjuvant therapy recommendations for invasive, nonmetastatic breast cancer.

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