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. 2025 Nov 8:S0022-5223(25)00972-9.
doi: 10.1016/j.jtcvs.2025.10.040. Online ahead of print.

Changes in patient-reported quality of life after lobectomy versus sublobar resection

Danny Wang  1 , Zhengyu Fang  2 , Alexander Zhu  1 , Bryan Rettner  1 , Alexandra L Potter  1 , Meghan McCarthy  1 , Lizi Zhang  2 , Joshua Kim  1 , Yuhang Zhang  2 , Joseph Powell  2 , Aubrey Pope  1 , Jorind Beqari  1 , James Cranor  1 , Gabriel Smock  1 , Isha Mehta Warikoo  1 , Anna Aaron  1 , Quiana Guo  1 , Gina Hanna  1 , Joseph Mitri  1 , Michael Zarif  1 , Anton Melki  1 , Isaac Wilkins  1 , Mong-Wei Lin  3 , Hang Lee  1 , Christina Costantino  1 , Paul W Furlow  1 , Uma M Sachdeva  1 , Hugh G Auchincloss  1 , Cameron Wright  1 , Michael Lanuti  1 , Xiao Li  2 , Chi-Fu Jeffrey Yang  4
Affiliations

Changes in patient-reported quality of life after lobectomy versus sublobar resection

Danny Wang et al. J Thorac Cardiovasc Surg. .

Abstract

Objective: To evaluate differences in patient-reported quality of life after lobectomy versus sublobar resection.

Methods: This was a retrospective analysis of patients enrolled in a prospective trial evaluating recovery after thoracic surgery using wearable devices and patient-reported outcome measures. Patients who underwent elective lobectomy or sublobar resection were included. Patients wore a wearable device preoperatively to postoperative day 90 and completed the 36-Item Short Form Survey (SF-36) preoperatively and on postoperative days 30 and 90. SF-36 total, Physical Component Summary (PCS), and Mental Component Summary (MCS) scores at each timepoint were compared between patients who underwent lobectomy and those who underwent sublobar resection in both the overall cohort and a propensity score-matched cohort. Changes in SF-36 scores from baseline to postoperative day 30 and day 90 were compared in the lobectomy and sublobar resection groups using multivariable-adjusted linear regression models.

Results: A total of 30 patients undergoing lobectomy and 55 undergoing sublobar resection were included. In both groups, overall quality of life was significantly lower at 30 days postoperatively compared to preoperatively but recovered to baseline levels by 90 days postoperatively. There were no significant differences in quality-of-life scores preoperatively and at 30 days and 90 days postoperatively between the 2 groups in unadjusted analysis or propensity score-matched analysis. There were also no statistically significant differences in changes in the SF-36, PCS, or MCS scores from baseline to postoperative day 30 and 90 between the 2 groups.

Conclusions: In this retrospective analysis, patients undergoing lobectomy and those undergoing sublobar resection reported similar changes in quality of life after surgery.

Keywords: lobectomy; patient-reported outcome measures; quality of life; sublobar resection.

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Conflict of interest statement

Conflict of Interest Statement Dr Yang serves on advisory boards for AstraZeneca and Genentech and has received honoraria from AstraZeneca. Dr Auchincloss is a consultant for and has received honoraria from Intuitive Surgical. All other authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.

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