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. 2025 Nov 11.
doi: 10.1097/EJA.0000000000002308. Online ahead of print.

Intra-operative physiologic interventions associated with postoperative neurological complications in neonates and infants: A secondary analysis of the NECTARINE cohort

Virginia E Tangel  1 , Sanne E Hoeks, Laszlo Vutskits, Robert Jan Stolker, Nicola Disma, Jurgen C de Graaff; on behalf of the NECTARINE Group of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network
Collaborators, Affiliations

Intra-operative physiologic interventions associated with postoperative neurological complications in neonates and infants: A secondary analysis of the NECTARINE cohort

Virginia E Tangel et al. Eur J Anaesthesiol. .

Abstract

Background: Neonates and infants are among the most vulnerable populations to undergo procedures necessitating general anaesthesia and are at risk for postoperative neurological complications. The objective of this study was to assess the association between interventions for intra-operative physiologic instability and the development of postoperative neurological complications in a cohort of neonates and infants undergoing operative and nonoperative procedures.

Methods: Data for this study were extracted from the NECTARINE study: a prospectively collected cohort of neonates and infants receiving anaesthesia for operative and nonoperative procedures from 165 participating hospitals in 31 countries.In a multivariable logistic regression model predicting the development of a neurologic complication up to 30 days postoperatively, exposures of interest were binary indicators of unexpected intra-operative instability of systemic homeostasis necessitating a corrective action (based on blood pressure, heart rate, end-tidal and/or blood CO 2 , glucose and sodium).

Results: One hundred and forty out of 5504 (2.5%) neonates and infants developed a postoperative neurologic complication. No statistically significant association was found between interventions for intra-operative physiologic instability and the development of a postoperative neurologic complication.

Conclusion: In this secondary analysis of neonates and infants undergoing cardiac and noncardiac procedures, we found a higher rate of neurologic complications compared to adult populations undergoing noncardiac surgery. There was no association between unexpected intra-operative instability of systemic homeostasis necessitating a corrective action and subsequent neurologic complications; however, these findings do not necessarily indicate the absence of any effect of physiological disturbances on neurologic outcomes.

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