Advancing the treatment of NTRK-fused pediatric solid tumors: lessons from the ADVL1823 study
- PMID: 41216434
- PMCID: PMC12597198
- DOI: 10.21037/tp-2025-572
Advancing the treatment of NTRK-fused pediatric solid tumors: lessons from the ADVL1823 study
Keywords: NTRK fusions; infantile fibrosarcoma (IFS); larotrectinib; pediatric oncology; tissue-agnostic therapy.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-572/coif). C.S.C.V. reports consulting and advisory role in Bayer. E.T.V. reports consulting or advisory role in Pfizer and Bayer. The authors have no other conflicts of interest to declare.
Comment on
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Larotrectinib for Newly Diagnosed Infantile Fibrosarcoma and Other Pediatric NTRK Fusion-Positive Solid Tumors (Children's Oncology Group ADVL1823).J Clin Oncol. 2025 Apr;43(10):1188-1197. doi: 10.1200/JCO-24-01854. Epub 2024 Dec 9. J Clin Oncol. 2025. PMID: 39652801
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