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Editorial
. 2025 Oct 31;13(5):51.
doi: 10.21037/atm-25-120. Epub 2025 Oct 28.

Lyophilized drug reservoir-integrated hydrogel-forming microarray patches for transdermal delivery of isoniazid and pyridoxine hydrochloride as a strategy to treat latent tuberculosis

Maria J Rey-Sanchez  1 , Katherine A Miranda-Muñoz  1 , Logan D Morton  2 , Gabriel J Rodriguez-Rivera  3 , David A Castilla-Casadiego  1
Affiliations
Editorial

Lyophilized drug reservoir-integrated hydrogel-forming microarray patches for transdermal delivery of isoniazid and pyridoxine hydrochloride as a strategy to treat latent tuberculosis

Maria J Rey-Sanchez et al. Ann Transl Med. .
No abstract available

Keywords: Hydrogel-forming microneedles (hydrogel-forming MNs); isoniazid (INH); latent tuberculosis (latent TB); pyridoxine hydrochloride; transdermal drug delivery (TDD).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-25-120/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic representation of the hydrogel-forming MAP with lyophilized reservoir for transdermal delivery of INH and pyridoxine HCl via MN swelling. HCl, hydrochloric acid; INH, isoniazid; MAP, microarray patch; MN, microneedle.
See this image and copyright information in PMC

Comment on

References

    1. Villar-Hernández R, Ghodousi A, Konstantynovska O, et al. Tuberculosis: current challenges and beyond. Breathe (Sheff) 2023;19:220166. 10.1183/20734735.0166-2022 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. Latent TB Infection in the United States – Published Estimates. 2024. Available online: https://www.cdc.gov/tb-data/latent-tb-infection-estimates/index.html
    1. Badrinath M, Chen RJ, John S. Isoniazid Toxicity. In: StatPearls. Treasure Island: StatPearls Publishing; 2024. - PubMed
    1. Soumya P, Yaseen M, Lakshmi PA, et al. A Descriptive Study on Treatment Adherence and Associated Factors in Patients Receiving Anti-TB Drugs. J Pharm Sci Comput Chem 2025;1:58-68.
    1. Hamed R, Abu Nahia BJ, Alkilani AZ, et al. Recent advances in microneedling-assisted cosmetic applications. Cosmetics 2024;11:51

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