Retraction notice to Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial [The Lancet Regional Health-Americas Volume 6, February 2022, 100142]

Affiliations

¹ Research Division, Cardresearch Cardiologia Assistencial e de Pesquisa, Pontifícia Universidade Catolica de Minas Gerais, Rua Domingos Vieira 300, Sala 606 Santa Efigenia, Belo Horizonte, Minas Gerais, Brazil.
² Department of Medicine, Pontifícia Universidade Catolica de Minas Gerais, Brazil.
³ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
⁴ Public Health Care Division, Ibirité, Brazil.
⁵ Brazil e Family Medicine, Mental and Public Health Department, Ouro Preto Federal University, Ouro Preto, Brazil.
⁶ Public Health Fellowship Program, Governador Valadares Public Health Authority, Brazil.
⁷ Department of Medicine, Juiz de Fora Federal University, Juiz de Fora, Brazil.
⁸ Public Health Care Division, Brumadinho, Brazil.
⁹ Cytel Inc., Vancouver, British Columbia, Canada.
¹⁰ Certara Inc., NJ, USA.

Gilmar Reis et al. Lancet Reg Health Am. 2025.

. 2025 Oct 21:51:101286.

doi: 10.1016/j.lana.2025.101286. eCollection 2025 Nov.

¹ Research Division, Cardresearch Cardiologia Assistencial e de Pesquisa, Pontifícia Universidade Catolica de Minas Gerais, Rua Domingos Vieira 300, Sala 606 Santa Efigenia, Belo Horizonte, Minas Gerais, Brazil.
² Department of Medicine, Pontifícia Universidade Catolica de Minas Gerais, Brazil.
³ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
⁴ Public Health Care Division, Ibirité, Brazil.
⁵ Brazil e Family Medicine, Mental and Public Health Department, Ouro Preto Federal University, Ouro Preto, Brazil.
⁶ Public Health Fellowship Program, Governador Valadares Public Health Authority, Brazil.
⁷ Department of Medicine, Juiz de Fora Federal University, Juiz de Fora, Brazil.
⁸ Public Health Care Division, Brumadinho, Brazil.
⁹ Cytel Inc., Vancouver, British Columbia, Canada.
¹⁰ Certara Inc., NJ, USA.

Abstract

[This retracts the article DOI: 10.1016/j.lana.2021.100142.].

Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial.
Reis G, Dos Santos Moreira Silva EA, Medeiros Silva DC, Thabane L, Cruz Milagres A, Ferreira TS, Quirino Dos Santos CV, de Figueiredo Neto AD, Diniz Callegari E, Monteiro Savassi LC, Campos Simplicio MI, Barra Ribeiro L, Oliveira R, Harari O, Bailey H, Forrest JI, Glushchenko A, Sprague S, McKay P, Rayner CR, Ruton H, Guyatt GH, Mills EJ. Reis G, et al. Lancet Reg Health Am. 2022 Feb;6:100142. doi: 10.1016/j.lana.2021.100142. Epub 2021 Dec 14. Lancet Reg Health Am. 2022. Retraction in: Lancet Reg Health Am. 2025 Oct 21;51:101286. doi: 10.1016/j.lana.2025.101286. PMID: 34927127 Free PMC article. Retracted.

1. Reis G., Augusto dos Santos Moreira Silva E., Medeiros Silva D.C., et al. Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial. Lancet Reg Health Am. 2022;6 - PMC - PubMed
1. Expression of concern - effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial. Lancet Reg Health Am. 2024;31 - PMC - PubMed