Kinetics of distribution of amphetamine in cats
- PMID: 412217
- DOI: 10.1007/BF00426782
Kinetics of distribution of amphetamine in cats
Abstract
The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxy-amphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.
Similar articles
-
A comparative study of the pharmacokinetics of amphetamine.Res Vet Sci. 1973 Mar;14(2):207-15. Res Vet Sci. 1973. PMID: 4805142 No abstract available.
-
Brain and plasma concentrations of amphetamine isomers in mice.J Pharmacol Exp Ther. 1978 Sep;206(3):586-94. J Pharmacol Exp Ther. 1978. PMID: 702323
-
The regional distribution of d-amphetamine and local glucose utilization in rat brain during continuous amphetamine administration.Exp Brain Res. 1981;43(3-4):281-8. doi: 10.1007/BF00238369. Exp Brain Res. 1981. PMID: 7196337
-
Comparative metabolism of dl-3H-amphetamine hydrochloride in tolerant and nontolerant cats.Proc West Pharmacol Soc. 1968;11:75-7. Proc West Pharmacol Soc. 1968. PMID: 5734492 No abstract available.
-
Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration.J Pharmacol Exp Ther. 2000 Mar;292(3):1042-7. J Pharmacol Exp Ther. 2000. PMID: 10688621
Cited by
-
Clinical pharmacology of the perinatal period and early infancy.Clin Pharmacokinet. 1989;17 Suppl 1:13-28. doi: 10.2165/00003088-198900171-00004. Clin Pharmacokinet. 1989. PMID: 2692936 Review.
-
A Case of Amphetamine and Methamphetamine Intoxication in Cat.Toxics. 2022 Dec 1;10(12):749. doi: 10.3390/toxics10120749. Toxics. 2022. PMID: 36548582 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous