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Review
. 2025 Nov 11;58(11):2609-2612.
doi: 10.1016/j.immuni.2025.10.019.

Aging and immunity

Christoph A Thaiss, Ye Tian, Daniel A Winer, Michelle Linterman, Adrian Liston, Corina Amor, Scott W Lowe, Guang-Hui Liu
Review

Aging and immunity

Christoph A Thaiss et al. Immunity. .

Abstract

Time marches endlessly on … but what does that mean for the immune system? Here, investigators discuss how aging impacts the immune response and how immune cells can shape the aging process, with broader implications for modifying immunity to improve not only longevity but also health span.

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Conflict of interest statement

Declaration of interests C.A. is listed as the inventor of several patent applications (62/800,188; 63/174,277; 63/209,941; 63/209,940; 63/209,915; 63/209,924; 17/426,728; 3,128,368; 20748891.7; 2020216486; 63/510,997) related to senolytic CAR T cells. M.A.L. receives funding from GSK for work outside of this piece. D.A.W. is a co-founder of Cosmica Biosciences, a company that studies altered biological aging in spaceflight exposures. D.A.W. has patent applications related to this topic: “Methods for Simulating Inflammatory Aging, Cardiac Dysfunction, Neural Dysfunction, and Changes Associated with Spaceflight in Cells and Organoids, and Methods for Identifying and using Compounds Useful for Treatment of Cellular Changes Associated with Inflammatory Aging, Cardiac Dysfunction, Neural Dysfunction, and Spaceflight” (PCT/US2024/042658, WO 2025/038925).

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