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. 1973 Jun 1;180(4089):972-4.
doi: 10.1126/science.180.4089.972.

Molecular relatedness of mammalian RNA tumor viruses as determined by DNA hybridization

D K Haapala, P J Fischinger

Molecular relatedness of mammalian RNA tumor viruses as determined by DNA hybridization

D K Haapala et al. Science. .

Abstract

Each of six mammalian C-type viruses-including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114-can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA . RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids.

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